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Why Fasting Increases Longevity | Become Resilient to Stress
Use Fasting To Burn Body Fat & Get In Shape: http://bit.ly/2Mu9pxu Click Here to Check Out & Subscribe to Thomas' Channel: http://Bit.ly/ThomasVid Why Fasting Increases Longevity | Become Resilient to Stress - Thomas DeLauer Study - Rejuvenation Research To understand how fasting might make cells stronger, researchers recruited 24 people and asked them to practice an intermittent fasting diet for two three-week periods The study was designed as a 10-week double-crossover trial, consisting of two 3-week treatment periods - IF and IF with antioxidant supplementation Each 3-week treatment period was preceded by a 1-week pre-conditioning period used to establish baseline caloric intake and to acclimate the participants to study-provided food. During the first fasting period, participants ate a specially calibrated diet and during the second three week period, they ate that diet and took oral supplements of Vitamin C and Vitamin E Because researchers just wanted to focus on how intermittent fasting affected cells, and not weight loss, participants ate 175% of their normal daily calorie intake on feasting days, and 25% of their normal daily intake on fasting days to prevent weight loss During the first three week period researchers attempted to see if fasting would increase oxidative stress (free radicals) in each person’s cells and to see if this stress actually led to stronger, more resilient cells Looked to see if taking antioxidants in the second fasting period would block the free radicals caused by the fasting, preventing the cells from becoming more resilient In other words, they wanted to know if Vitamin C and E would shelter the cells to the point that they wouldn’t be ready to stand up for themselves later on Results Found that in response to fasting every other day, the cells made more copies of a gene called SIRT3, which is part of a pathway that works to prevent free radical production and improve cellular repair processes Specifically, there was a 2.7% increase in SIRT3 expression due to the IF diet, but no change in expression of other genes or oxidative stress markers analyzed Also found a significant decrease in levels of circulating insulin, a sign that the participants bodies were more responsive to this hormone One surprising finding is that when participants took daily oral supplements of Vitamin C and E, the benefits from fasting disappeared It seems that because the cells were relatively sheltered from experiencing any oxidative stress that may have been caused by fasting every other day, they didn’t respond by increasing their natural defenses and improving their sensitivity to insulin and other stress signals SIRT3 SIRT3 is the principal mitochondrial deacetylase that plays essential roles in mitochondrial functions: ATP production, reactive oxygen species (ROS) management, β-oxidation, ketogenesis, and cell death among other processes SIRT3 is a mitochondrial protein and has also been studied in regards to longevity and metabolic syndrome It is involved in controlling reactive oxygen species in the cell as higher levels of SIRT3 are connected to longevity - SIRT3 exhibits NAD+-dependent deacetylase activity SIRT3 & Antioxidant Defense As we know, free radicals such as superoxide can cause considerable oxidative damage to proteins, lipids, and DNA, consequently expediting aging, cancer, and neurodegeneration SIRT3 directly deacetylates MnSOD (manganese superoxide dismutase, mitochondrial antioxidant) in mitochondria, significantly enhancing its ability to scavenge ROS (over 90% of cellular ROS is produced by mitochondria as electrons escape the ETC to combine with molecular O2 producing superoxide anions) SIRT3 also deacetylates IDH2, causing an increase in its activity - IDH2 is an enzyme of the tricarboxylic acid cycle which produces NADPH, a molecule implicated in the regeneration of antioxidants Enhanced activity of IDH2 by SIRT3-mediated deacetylation produces increased levels of NADPH, which in turn can increase the activity of glutathione reductase to further facilitate regeneration of GSH from GSSG As always, keep it locked in on the channel, and don't forget to: "Like" "Share" & "Subscribe" to SixPackAbs.com I'll see you next time, -Thomas Achieve The Body You Deserve: http://bit.ly/2Mu9pxu P.S. Make sure to Like & Share this video on Facebook: https://youtu.be/SElE341v8i4 References 1) Fasting Might Make Our Cells More Resilient to Stress - h+ Media. (2015, March 30). Retrieved from http://bit.ly/1abBohC 2) Mary Ann Liebert | Error. (n.d.). Retrieved from http://bit.ly/2Mu9q4w 3) Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration. (n.d.). Retrieved from http://bit.ly/2sILSzV
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Use Fasting To Burn Body Fat & Get In Shape: http://bit.ly/2Mu9pxu Click Here to Check Out & Subscribe to Thomas' Channel: http://Bit.ly/ThomasVid Why Fasting Increases Longevity | Become Resilient to Stress - Thomas DeLauer Study - Rejuvenation Research To understand how fasting might make cells stronger, researchers recruited 24 people and asked them to practice an intermittent fasting diet for two three-week periods The study was designed as a 10-week double-crossover trial, consisting of two 3-week treatment periods - IF and IF with antioxidant supplementation Each 3-week treatment period was preceded by a 1-week pre-conditioning period used to establish baseline caloric intake and to acclimate the participants to study-provided food. During the first fasting period, participants ate a specially calibrated diet and during the second three week period, they ate that diet and took oral supplements of Vitamin C and Vitamin E Because researchers just wanted to focus on how intermittent fasting affected cells, and not weight loss, participants ate 175% of their normal daily calorie intake on feasting days, and 25% of their normal daily intake on fasting days to prevent weight loss During the first three week period researchers attempted to see if fasting would increase oxidative stress (free radicals) in each person’s cells and to see if this stress actually led to stronger, more resilient cells Looked to see if taking antioxidants in the second fasting period would block the free radicals caused by the fasting, preventing the cells from becoming more resilient In other words, they wanted to know if Vitamin C and E would shelter the cells to the point that they wouldn’t be ready to stand up for themselves later on Results Found that in response to fasting every other day, the cells made more copies of a gene called SIRT3, which is part of a pathway that works to prevent free radical production and improve cellular repair processes Specifically, there was a 2.7% increase in SIRT3 expression due to the IF diet, but no change in expression of other genes or oxidative stress markers analyzed Also found a significant decrease in levels of circulating insulin, a sign that the participants bodies were more responsive to this hormone One surprising finding is that when participants took daily oral supplements of Vitamin C and E, the benefits from fasting disappeared It seems that because the cells were relatively sheltered from experiencing any oxidative stress that may have been caused by fasting every other day, they didn’t respond by increasing their natural defenses and improving their sensitivity to insulin and other stress signals SIRT3 SIRT3 is the principal mitochondrial deacetylase that plays essential roles in mitochondrial functions: ATP production, reactive oxygen species (ROS) management, β-oxidation, ketogenesis, and cell death among other processes SIRT3 is a mitochondrial protein and has also been studied in regards to longevity and metabolic syndrome It is involved in controlling reactive oxygen species in the cell as higher levels of SIRT3 are connected to longevity - SIRT3 exhibits NAD+-dependent deacetylase activity SIRT3 & Antioxidant Defense As we know, free radicals such as superoxide can cause considerable oxidative damage to proteins, lipids, and DNA, consequently expediting aging, cancer, and neurodegeneration SIRT3 directly deacetylates MnSOD (manganese superoxide dismutase, mitochondrial antioxidant) in mitochondria, significantly enhancing its ability to scavenge ROS (over 90% of cellular ROS is produced by mitochondria as electrons escape the ETC to combine with molecular O2 producing superoxide anions) SIRT3 also deacetylates IDH2, causing an increase in its activity - IDH2 is an enzyme of the tricarboxylic acid cycle which produces NADPH, a molecule implicated in the regeneration of antioxidants Enhanced activity of IDH2 by SIRT3-mediated deacetylation produces increased levels of NADPH, which in turn can increase the activity of glutathione reductase to further facilitate regeneration of GSH from GSSG As always, keep it locked in on the channel, and don't forget to: "Like" "Share" & "Subscribe" to SixPackAbs.com I'll see you next time, -Thomas Achieve The Body You Deserve: http://bit.ly/2Mu9pxu P.S. Make sure to Like & Share this video on Facebook: https://youtu.be/SElE341v8i4 References 1) Fasting Might Make Our Cells More Resilient to Stress - h+ Media. (2015, March 30). Retrieved from http://bit.ly/1abBohC 2) Mary Ann Liebert | Error. (n.d.). Retrieved from http://bit.ly/2Mu9q4w 3) Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration. (n.d.). Retrieved from http://bit.ly/2sILSzV
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